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中文人类
PDK3 - Pyruvate Dehydrogenase Kinase 3
Alias:
CMTX6
GS1-358P8.4
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丙酮酸脱氢酶（PDH）复合体是一种核编码线粒体多酶复合体，催化丙酮酸总体转化为乙酰辅酶A和CO2。它在糖酵解和三羧酸（TCA）循环之间提供主要联系，因此是负责调节葡萄糖代谢的主要酶之一。PDH的酶活性受到磷酸化/脱磷酸化循环的调节，磷酸化导致PDH失活。此基因编码的蛋白质是三种丙酮酸脱氢酶激酶之一，通过E1α亚单位的磷酸化抑制PDH复合体。此基因主要在心脏和骨骼肌中表达。已发现此基因的不同剪接转录变体，编码不同的异构体。[RefSeq，2010年3月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PDK3 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
