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中文人类
PDGFRB - Platelet Derived Growth Factor Receptor Beta
Alias:
IMF1
KOGS
IBGC4
JTK12
PDGFR
PENTT
CD140B
PDGFR1
PDGFR-1
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这个基因编码的蛋白质是一种细胞表面酪氨酸激酶受体，用于血小板来源的生长因子家族的成员。这些生长因子是间充质来源的细胞的促细胞分裂剂。与受体单体结合的生长因子的身份决定了功能性受体是同二聚体（PDGFB或PDGFD）还是异二聚体（PDGFA和PDGFB）。这个基因对心血管系统的正常发育是必不可少的，并有助于重组肌动蛋白细胞骨架。这个基因在染色体5上由粒细胞-巨噬细胞集落刺激因子和巨噬细胞集落刺激因子受体的基因两侧；所有这三个基因可能与5-q综合征有关。染色体5和12之间的易位，将这个基因与ETV6基因融合，导致慢性骨髓增殖性嗜酸性白细胞过多症。[RefSeq,2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PDGFRB Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
