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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
TLR7 - Toll Like Receptor 7
Alias:
IMD74
SLEB17
TLR7-like
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是Toll样受体(TLR)家族的一员,在病原体识别和先天免疫激活中起基本作用。TLRs从果蝇到人类高度保守,并在结构和功能上相似。人类TLR家族包括11个成员。它们识别感染剂上表达的病原体相关分子模式(PAMPs),并调节有效免疫发展所需细胞因子的产生。为了识别外来微生物中的结构成分,各种TLR以不同的方式表达;例如,TLR-3、-7和-8在识别单链RNA病毒方面是必不可少的。TLR7感知来自RNA病毒的富含鸟苷和尿嘧啶的单链RNA寡核苷酸,这种识别在质浆细胞样树突状细胞和B细胞的内质体中发生。这个基因主要在肺、胎盘和脾中表达,并与另一个家庭成员TLR8在染色体X上紧密相邻,并在系统发育上有关。[由RefSeq,2020年8月提供]
Related ID:
NCBI:51284
ENSEMBL:ENSG00000196664
HGNC:15631
UNIPROT:Q9NYK1
OMIM:300365
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
51284
1
3
23290 bp
120.92
116
4
16
16
TLR7 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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