人类

TLR7 - Toll Like Receptor 7

Alias:
IMD74
SLEB17
TLR7-like
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是Toll样受体(TLR)家族的一员,在病原体识别和先天免疫激活中起基本作用。TLRs从果蝇到人类高度保守,并在结构和功能上相似。人类TLR家族包括11个成员。它们识别感染剂上表达的病原体相关分子模式(PAMPs),并调节有效免疫发展所需细胞因子的产生。为了识别外来微生物中的结构成分,各种TLR以不同的方式表达;例如,TLR-3、-7和-8在识别单链RNA病毒方面是必不可少的。TLR7感知来自RNA病毒的富含鸟苷和尿嘧啶的单链RNA寡核苷酸,这种识别在质浆细胞样树突状细胞和B细胞的内质体中发生。这个基因主要在肺、胎盘和脾中表达,并与另一个家庭成员TLR8在染色体X上紧密相邻,并在系统发育上有关。[由RefSeq,2020年8月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
3
23290 bp
120.92
116
4
16
16

TLR7 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
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