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中文人类
CLDN18 - Claudin 18
Alias:
SFTA5
SFTPJ
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这个基因编码claudin家族的一员。Claudins是整合膜蛋白，是紧密连接链的组成部分。紧密连接链作为物理屏障，防止溶质和水分自由通过上皮或内皮细胞片之间的胞间间隙，同时也在维持细胞极性和信号传导中起到关键作用。这个基因在溃疡性结肠炎患者中上调，并在浸润性导管腺癌中高度过表达。PKC/MAPK/AP-1（蛋白激酶C/有丝分裂原激活蛋白激酶/激活蛋白-1）依赖的途径在胃细胞中调节这个基因的表达。已经发现了编码不同异构体的可变剪接转录本。[由RefSeq，2010年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CLDN18 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
