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中文人类
SOST - Sclerostin
Alias:
CDD
VBCH
DAND6
SOST1
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硬骨蛋白是一种分泌性糖蛋白，具有C-末端半胱氨酸结样(CTCK)结构域，并与神经母细胞瘤中差异筛选选择的基因异常(DAN)家族骨形态发生蛋白(BMP)拮抗剂具有序列相似性。该基因的失功能突变与常染色体隐性紊乱硬骨病有关，导致骨生长过度。该基因下游的缺失导致sclerostin表达减少，与称为van Buchem病的较轻形式的疾病相关。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SOST Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
