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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PCBP1 - Poly(rC) Binding Protein 1
Alias:
HNRPX
HNRPE1
hnRNP-X
HEL-S-85
hnRNP-E1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个无内含子的基因被认为是通过完全处理的PCBP-2 mRNA逆转录产生的。这个基因和PCBP-2有同源基因(PCBP3和PCBP4),被认为是由整个基因的复制事件产生的。这个基因编码的蛋白质具有多种功能。它与PCBP-2和hnRNPK一起作为主要细胞poly(rC)结合蛋白。它包含三个K-同源(KH)结构域,可能涉及RNA结合。这个编码的蛋白质与PCBP-2一起作为脊髓灰质炎病毒RNA的翻译协同激活因子,通过与IRES的茎环IV的序列特异性相互作用,并通过与其5'端四联结构结合来促进脊髓灰质炎病毒RNA复制。它还涉及15-脂氧合酶mRNA、人乳头瘤病毒16型L2 mRNA和甲型肝炎病毒RNA的翻译控制。这个编码的蛋白质也被认为在形成与α-珠蛋白mRNA稳定性相关的序列特异性的α-珠蛋白mRNP复合体中发挥作用。[由RefSeq,2008年7月提供]
Related ID:
NCBI:5093
ENSEMBL:ENSG00000169564
HGNC:8647
UNIPROT:Q15365
OMIM:601209
Basic Information
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Mutations
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Reference
5093
1
1
1727 bp
37.50
4
--
6
23
PCBP1 Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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