人类

PCBP1 - Poly(rC) Binding Protein 1

Alias:
HNRPX
HNRPE1
hnRNP-X
HEL-S-85
hnRNP-E1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个无内含子的基因被认为是通过完全处理的PCBP-2 mRNA逆转录产生的。这个基因和PCBP-2有同源基因(PCBP3和PCBP4),被认为是由整个基因的复制事件产生的。这个基因编码的蛋白质具有多种功能。它与PCBP-2和hnRNPK一起作为主要细胞poly(rC)结合蛋白。它包含三个K-同源(KH)结构域,可能涉及RNA结合。这个编码的蛋白质与PCBP-2一起作为脊髓灰质炎病毒RNA的翻译协同激活因子,通过与IRES的茎环IV的序列特异性相互作用,并通过与其5'端四联结构结合来促进脊髓灰质炎病毒RNA复制。它还涉及15-脂氧合酶mRNA、人乳头瘤病毒16型L2 mRNA和甲型肝炎病毒RNA的翻译控制。这个编码的蛋白质也被认为在形成与α-珠蛋白mRNA稳定性相关的序列特异性的α-珠蛋白mRNP复合体中发挥作用。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
1
1727 bp
37.50
4
--
6
23

PCBP1 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
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