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中文人类
PAWR - Pro-apoptotic WT1 Regulator
Alias:
PAR4
Par-4
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这个基因编码一种肿瘤抑制蛋白，通过细胞内和细胞外机制有选择地在癌细胞中诱导凋亡。细胞内机制涉及抑制生存通路和激活Fas介导的凋亡，而细胞外机制涉及这个蛋白的分泌形式与细胞表面的葡萄糖调节蛋白78（GRP78）结合，从而激活外在凋亡途径。这个基因位于不稳定的人类12号染色体q21区域，常常在不同肿瘤中缺失或突变。编码的蛋白在年龄相关疾病的发展中也扮演重要角色。[RefSeq，2017年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PAWR Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
