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中文人类
PARN - Poly(A)-specific Ribonuclease
Alias:
DAN
DKCB6
PFBMFT4
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这个基因编码的蛋白质是一种3'-外切核糖核酸酶，与3'-核酸酶D家族具有相似性。它更喜欢poly(A)作为底物，因此有效地降解mRNA的poly(A)尾。核酶降解poly(A)尾通常是真核mRNA衰变的第一个步骤。这个蛋白质也参与卵母细胞成熟和早期胚胎发育过程中某些母源mRNA的沉默，以及参与含有提前终止密码子的mRNA的谬误介导的衰减（NMD）。已经发现这个基因的不同剪接转录变异体编码不同的异构体。[由RefSeq，2008年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PARN Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
