Ptk2b - protein tyrosine kinase 2 beta

Enables 3-phosphoinositide-dependent protein kinase binding activity; calmodulin-dependent protein kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell communication; and positive regulation of cellular biosynthetic process. Located in several cellular components, including dendrite; focal adhesion; and postsynaptic density. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynapse. Used to study brain ischemia; diabetic angiopathy; and nephritis. Biomarker of anti-basement membrane glomerulonephritis; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]