人类

IL21R - Interleukin 21 Receptor

Alias:
NILR
CD360
IMD56
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种白细胞介素21(IL21)的细胞因子受体。它属于I型细胞因子受体,已经证明可以与共同的γ链形成异源二聚体受体复合物,该受体亚单位也由白细胞介素2、4、7、9和15的受体共享。这个受体传递IL21的生长促进信号,对于T细胞、B细胞和自然杀手(NK)细胞的增殖和分化非常重要。这个受体的配体结合导致多个下游信号分子激活,包括JAK1、JAK3、STAT1和STAT3。小鼠中类似基因的敲除研究提示这个基因在调节免疫球蛋白产生中发挥作用。已经描述了三种可变剪接转录变异体。[RefSeq,2010年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6
9
49869 bp
59.13
319
1
7
9

IL21R Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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