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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL21R - Interleukin 21 Receptor
Alias:
NILR
CD360
IMD56
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种白细胞介素21(IL21)的细胞因子受体。它属于I型细胞因子受体,已经证明可以与共同的γ链形成异源二聚体受体复合物,该受体亚单位也由白细胞介素2、4、7、9和15的受体共享。这个受体传递IL21的生长促进信号,对于T细胞、B细胞和自然杀手(NK)细胞的增殖和分化非常重要。这个受体的配体结合导致多个下游信号分子激活,包括JAK1、JAK3、STAT1和STAT3。小鼠中类似基因的敲除研究提示这个基因在调节免疫球蛋白产生中发挥作用。已经描述了三种可变剪接转录变异体。[RefSeq,2010年7月提供]
Related ID:
NCBI:50615
ENSEMBL:ENSG00000103522
HGNC:6006
UNIPROT:Q9HBE5
OMIM:605383
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
50615
6
9
49869 bp
59.13
319
1
7
9
IL21R Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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