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中文人类
PAK1 - P21 (RAC1) Activated Kinase 1
Alias:
IDDMSSD
p65-PAK
PAKalpha
alpha-PAK
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这个基因编码一种丝氨酸/苏氨酸p21激活激酶家族成员，被称为PAK蛋白。这些蛋白质作为将RhoGTP酶与细胞骨架重组和核信号传导连接的关键效应子，并作为小GTP结合蛋白Cdc42和Rac的靶点。这个特定的家族成员调节细胞运动和形态。这个基因的突变与巨头症、癫痫和语言延迟有关。这个基因的过度表达在许多癌症类型中都有报道，特别是在乳腺癌中。可变剪接导致多个转录变异体。[由RefSeq，2020年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PAK1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
