Gja5 - gap junction protein, alpha 5

Enables connexin binding activity; disordered domain specific binding activity; and gap junction channel activity. Involved in several processes, including blood vessel diameter maintenance; cell communication by chemical coupling; and regulation of blood pressure. Located in cell projection. Part of connexin complex. Used to study hypertension. Biomarker of artery disease (multiple); glomerulonephritis; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (gap junction protein alpha 5). [provided by Alliance of Genome Resources, Apr 2022]