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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
大鼠
Txnrd2 - thioredoxin reductase 2
Alias:
Tr3
Trxr2
Trxrd2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质属于吡啶核苷酸-二硫化物氧化还原酶家族,是硫氧还蛋白(Trx)系统的一员。在哺乳动物中发现了三种硫氧还蛋白还原酶(TrxR)同功酶。TrxR是含硒半胱氨酸的黄酶,可以还原硫氧还蛋白以及其他底物,并在氧化还原内稳态中起到关键作用。这个基因编码一个线粒体形式的蛋白质,对线粒体中反应性氧物质的清除非常重要。它作为含有FAD和活性位点硒半胱氨酸(Sec)的同源二聚体发挥作用。Sec由UGA密码子编码,通常作为翻译终止信号。硒蛋白mRNA的3'UTR含有保守的茎环结构,即Sec插入序列(SECIS)元件,这是将UGA识别为Sec密码子而非终止信号所必需的。[RefSeq,2017年6月提供]
Related ID:
NCBI:50551
ENSEMBL:ENSRNOG00000001890
UNIPROT:Q9Z0J5
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
50551
1
18
48161 bp
56.58
5
3
Txnrd2 Genetics information (-)
mRatBN7.2
Sequence Homology
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
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