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Txnrd2 - thioredoxin reductase 2

Alias:
Tr3
Trxr2
Trxrd2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质属于吡啶核苷酸-二硫化物氧化还原酶家族,是硫氧还蛋白(Trx)系统的一员。在哺乳动物中发现了三种硫氧还蛋白还原酶(TrxR)同功酶。TrxR是含硒半胱氨酸的黄酶,可以还原硫氧还蛋白以及其他底物,并在氧化还原内稳态中起到关键作用。这个基因编码一个线粒体形式的蛋白质,对线粒体中反应性氧物质的清除非常重要。它作为含有FAD和活性位点硒半胱氨酸(Sec)的同源二聚体发挥作用。Sec由UGA密码子编码,通常作为翻译终止信号。硒蛋白mRNA的3'UTR含有保守的茎环结构,即Sec插入序列(SECIS)元件,这是将UGA识别为Sec密码子而非终止信号所必需的。[RefSeq,2017年6月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
1
18
48161 bp
56.58
5
3

Txnrd2 Genetics information (-)

mRatBN7.2

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
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