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中文人类
SERPINE1 - Serpin Family E Member 1
Alias:
PAI
PAI1
PAI-1
PLANH1
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这个基因编码丝氨酸蛋白酶抑制剂（丝氨酸蛋白酶抑制剂）超家族的一员。这个成员是组织纤溶酶原激活剂（tPA）和尿激酶（uPA）的主要抑制剂，因此也是纤维蛋白溶解的抑制剂。该蛋白质还作为先天抗病毒免疫的成分发挥作用。这个基因的缺陷是导致纤溶酶原激活剂抑制剂-1（PAI-1）缺陷的原因，并且该基因产物的较高浓度与血栓形成倾向有关。[RefSeq，2020年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SERPINE1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
