Huwe1 - HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

Enables DNA binding activity. Predicted to be involved in several processes, including circadian regulation of gene expression; positive regulation of protein metabolic process; and protein ubiquitination. Located in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]