Cyp11b1 - cytochrome P450, family 11, subfamily b, polypeptide 1

Enables steroid 11-beta-monooxygenase activity and steroid binding activity. Involved in several processes, including cellular response to interferon-gamma; primary alcohol biosynthetic process; and response to dexamethasone. Located in mitochondrion. Is integral component of endoplasmic reticulum membrane. Used to study hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]