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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
OSM - Oncostatin M
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码白血病抑制因子/巨细胞刺激素-M(LIF/OSM)家族的一员。编码的前原蛋白在蛋白水解过程中被加工成成熟蛋白。这种蛋白质是一种分泌型细胞因子和生长调节剂,可抑制多种肿瘤细胞系的增殖。该蛋白质还调节其他细胞因子的产生,包括内皮细胞中的白细胞介素6、粒细胞-集落刺激因子和粒细胞-巨噬细胞集落刺激因子。这个基因和相关基因,即也在染色体22上存在的白血病抑制因子,可能源于一个共同祖先基因的复制。可变剪接导致多个转录变异体,至少其中一个编码经蛋白水解加工的异构体。[由RefSeq,2016年1月提供]
Related ID:
NCBI:5008
ENSEMBL:ENSG00000099985
HGNC:8506
UNIPROT:P13725
OMIM:165095
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5008
3
3
4023 bp
28.48
24
--
6
12
OSM Genetics information (-)
GRCh38
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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