Ubr1 - ubiquitin protein ligase E3 component n-recognin 1

Predicted to enable leucine binding activity and ubiquitin-protein transferase activity. Predicted to be involved in cellular response to leucine and negative regulation of TOR signaling. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex and ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1). [provided by Alliance of Genome Resources, Apr 2022]