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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
ORC1 - Origin Recognition Complex Subunit 1
Alias:
ORC1L
PARC1
HSORC1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个句子可以翻译为:“ORC(起源识别复合体)是一种高度保守的由六个亚基组成的蛋白质复合体,对于真核细胞中DNA复制的起始是必不可少的。在酵母中的研究表明,ORC特异性地结合到复制起点,并作为其他起始因子如Cdc6和Mcm蛋白质组装的平台。这个基因编码的蛋白质是ORC复合体最大的亚基。虽然其他ORC亚基在整个细胞周期中稳定,但这个蛋白质的水平在细胞周期中变化,已经证明在DNA复制开始后受到泛素介导的蛋白水解的调控。这个蛋白质在有丝分裂过程中被选择性地磷酸化。据报道,它还可以与MYST组蛋白乙酰转移酶2(MyST2/HBO1)相互作用,这是一种参与转录沉默控制的蛋白质。已经发现这个基因的不同剪接转录变异体编码不同的异构体。”
Related ID:
NCBI:4998
ENSEMBL:ENSG00000085840
HGNC:8487
UNIPROT:Q13415
OMIM:601902
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
4998
7
17
36675 bp
97.35
279
1
6
19
ORC1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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No data available
Transcripts & Proteins
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Transcript
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No data available
* This data comes from NCBI.
Gene Expression
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