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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
MMP14 - Matrix Metallopeptidase 14
Alias:
MMP-14
MMP-X1
MT-MMP
MT1MMP
MTMMP1
WNCHRS
MT1-MMP
MT-MMP 1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
基质金属蛋白酶(MMP)家族的蛋白质涉及正常生理过程中细胞外基质的分解,如胚胎发育、繁殖和组织重塑,以及疾病过程中,如关节炎和转移。大多数MMP是以无活性的前蛋白质形式分泌的,当被细胞外蛋白酶切割时激活。然而,这个基因编码的蛋白质是膜型MMP(MT-MMP)亚家族的成员;这个亚家族的每个成员都包含一个潜在的跨膜结构域,表明这些蛋白质在细胞表面表达而不是分泌。这个蛋白质激活MMP2蛋白质,这个活性可能涉及肿瘤侵袭。[由RefSeq,2008年7月提供]
Related ID:
NCBI:4323
ENSEMBL:ENSG00000157227
HGNC:7160
UNIPROT:P50281
OMIM:600754
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
4323
1
10
11174 bp
65.89
208
2
16
19
MMP14 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
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Transcript
Length(nt)
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Length(aa)
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Cell-specific RNA expression
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Name
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CAS Number
Status
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Link
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References Literature
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