Zfp457 - zinc finger protein 457

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; negative regulation of transposon integration; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF208 (zinc finger protein 208); and ZNF43 (zinc finger protein 43). [provided by Alliance of Genome Resources, Apr 2022]