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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
MMP7 - Matrix Metallopeptidase 7
Alias:
MMP-7
MPSL1
PUMP-1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码肽酶M10家族的成员,该家族成员参与正常生理过程中细胞外基质的分解,如胚胎发育、繁殖和组织重塑,以及疾病过程中,如关节炎和转移。编码的前原原蛋白在蛋白水解过程中被加工成成熟的蛋白酶。这种分泌的蛋白酶分解蛋白聚糖、纤维连接蛋白、弹性蛋白和酪蛋白,并且与大多数MMP家族成员不同,它缺乏保守的C端血红蛋白域。该酶参与伤口愈合,并在小鼠中的研究表明,它调节肠道黏膜中防御素的活动。该基因是染色体11上MMP基因簇的一部分。该基因在多种人类癌症中表现出升高的表达水平。[RefSeq,2016年1月提供]
Related ID:
NCBI:4316
ENSEMBL:ENSG00000137673
HGNC:7174
UNIPROT:P09237
OMIM:178990
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
4316
1
6
10240 bp
29.68
14
--
4
7
MMP7 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
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No data available
Transcripts & Proteins
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#
Transcript
Length(nt)
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No data available
* This data comes from NCBI.
Gene Expression
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Name
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Status
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References Literature
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