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中文人类
MGMT - O-6-methylguanine-DNA Methyltransferase
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烷基化剂是强大的致癌剂，可能导致细胞死亡、突变和癌症。这个基因编码的蛋白质是一种DNA修复蛋白质，参与细胞防御突变和烷基化剂的毒性。该蛋白质催化O(6)-烷基鸟嘌呤和DNA的其他甲基化部分上的甲基基团转移到其自己的分子上，从而修复有毒损伤。基因启动子的甲基化与几种癌症类型有关，包括结直肠癌、肺癌、淋巴瘤和胶质母细胞瘤。[由RefSeq，2015年9月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MGMT Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
