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中文人类
MET - MET Proto-oncogene, Receptor Tyrosine Kinase
Alias:
DA11
HGFR
AUTS9
RCCP2
c-Met
DFNB97
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这个基因编码一种受体酪氨酸激酶家族的蛋白质成员，是原癌基因MET的产物。编码的前原蛋白在蛋白水解过程中被加工成α和β亚基，通过二硫键连接形成成熟的受体。β亚基的进一步加工形成M10肽，已显示其能减轻肺纤维化。其配体肝细胞生长因子的结合诱导受体二聚化并激活，参与细胞生存、胚胎发育和细胞迁移侵袭。这个基因的突变与乳头状肾细胞癌、肝细胞癌和各种头颈部癌症相关。这个基因的扩增和过表达也与多种人类癌症相关。[RefSeq提供，2016年5月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MET Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
