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中文人类
MCM3 - Minichromosome Maintenance Complex Component 3
Alias:
HCC5
P1.h
RLFB
P1-MCM3
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这个基因编码的蛋白质是高度保守的mini-染色体维持蛋白（MCM）之一，参与真核基因组复制的启动。MCM蛋白形成的六聚体蛋白质复合物是复制前复合物（pre_RC）的关键组成部分，可能参与复制叉的形成和其他DNA复制相关蛋白质的招募。这个蛋白质是MCM2-7蛋白质复合物的亚单位，已被证明直接与MCM5/CDC46相互作用。这个蛋白质还可以与染色质关联的乙酰转移酶MCM3AP相互作用并被其乙酰化。这个蛋白质的乙酰化抑制了DNA复制的启动和细胞周期进程。已经发现这个基因的几个转录变异体编码不同的异构体。[由RefSeq，2018年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MCM3 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
