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中文人类
SMAD7 - SMAD Family Member 7
Alias:
CRCS3
MADH7
MADH8
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这个基因编码的蛋白质是一种结合E3泛素连接酶SMURF2的核蛋白。在结合后，这个复合物转移到细胞质中，与TGF-beta受体1型（TGFBR1）相互作用，导致编码的蛋白质和TGFBR1的降解。这个基因的表达受到TGFBR1的诱导。这个基因的变异是3型结直肠癌（CRCS3）易感性的原因。已经发现这个基因有几个编码不同异型的转录变异体。[由RefSeq，2010年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SMAD7 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
