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中文人类
BMAL1 - Basic Helix-loop-helix ARNT Like 1
Alias:
TIC
JAP3
MOP3
ARNTL
PASD3
ARNTL1
BMAL1c
bHLHe5
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这个基因编码的蛋白质是一种与CLOCK形成异二聚体的基本螺旋-环-螺旋蛋白。这个异二聚体结合周期(PER1、PER2、PER3)和隐花色素(CRY1、CRY2)基因上游的E-box增强子元素，并激活这些基因的转录。PER和CRY蛋白通过与其CLOCK/ARNTL复合物在反馈环路中相互作用，实现其自身的转录抑制。这个基因的缺陷与不育、糖异生和脂生成问题以及睡眠模式的改变有关。这个蛋白质调节干扰素刺激的基因表达，是包括COVID-19在内的病毒感染的重要因素。[由RefSeq，2021年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
BMAL1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
