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中文人类
LRP5 - LDL Receptor Related Protein 5
Alias:
HBM
LR3
OPS
EVR1
EVR4
LRP7
OPPG
BMND1
LRP-5
LRP-7
OPTA1
PCLD4
VBCH2
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这个基因编码一个跨膜低密度脂蛋白受体，它在受体介导的内吞过程中结合并内化配体。这个蛋白质还作为与Frizzled蛋白质家族成员共同受体，通过Wnt蛋白质传递信号，最初是根据它与人类1型糖尿病的关联而被克隆的。这个蛋白质在骨骼稳态中起关键作用，许多骨密度相关疾病是由这个基因的突变引起的。这个基因的突变还会导致家族性渗出性玻璃体视网膜病变。可变剪接导致多个转录变异体。[由RefSeq提供，2014年5月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
LRP5 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
