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中文人类
LIMK2 - LIM Domain Kinase 2
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已知约40种真核生物LIM蛋白，因其含有的LIM结构域而命名。LIM结构域是高度保守的富含半胱氨酸结构，包含2个锌指。尽管锌指通常通过结合DNA或RNA发挥作用，但LIM基序可能调节蛋白质-蛋白质相互作用。LIM激酶-1和LIM激酶-2属于一个具有2个N端LIM基序和1个C端蛋白激酶结构域的独特小亚家族。此基因编码的蛋白质可被ROCK磷酸化并激活，ROCK是Rho的下游效应子，然后编码的蛋白质磷酸化cofilin，抑制其降解肌动蛋白的活性。认为此途径有助于Rho诱导肌动蛋白细胞骨架的重排。已在此基因中发现至少三种编码不同异型录本的转录变异体。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
LIMK2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
