人类

LCK - LCK Proto-oncogene, Src Family Tyrosine Kinase

Alias:
LSK
YT16
IMD22
p56lck
pp58lck
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因是Src家族酪氨酸激酶(PTKs)的成员。编码的蛋白质是选择和成熟发育中的T细胞的关键信号分子。它包含N端的甲基化和棕榈酰化位点,一个PTK域,以及SH2和SH3域,这些域参与介导与磷酸酪氨酸和富含脯氨酸的模式的蛋白质-蛋白质相互作用。该蛋白质定位在细胞膜和细胞周质中心体小窝,并结合细胞表面受体,包括CD4和CD8,以及其他信号分子。已经描述了编码不同亚型的多个可变剪接变体。[由RefSeq提供,2016年8月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
8
13
34901 bp
58.00
213
1
14
56

LCK Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
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Comparison
Al agent
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