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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Irs2 - insulin receptor substrate 2
Alias:
Irs-2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
磷脂酰肌醇3-激酶结合活性和蛋白激酶结合活性。参与几个过程,包括负调控B细胞凋亡过程;正调控B细胞增殖;以及正调控胰岛素分泌。在几个过程的上游或内部发挥作用,包括动物器官发育;胰岛素受体信号通路;以及正调控间充质细胞增殖。位于细胞质和质膜中。是含蛋白质复合物的一部分。在几个结构中表达,包括脑室层;后肢指皮肤;颌;肾单位;和胸腺原基。用于研究2型糖尿病。该基因的人类同源物与2型糖尿病有关。与人类的IRS2(胰岛素受体底物2)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:384783
ENSEMBL:ENSMUSG00000038894
UNIPROT:P81122
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
384783
1
2
24249 bp
136.76
11
6
Irs2 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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