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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Rrm2b - ribonucleotide reductase M2 B (TP53 inducible)
Alias:
p53R2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
核糖核苷酸二磷酸还原酶的激活,以硫氧还蛋白二硫化物作为受体。在几个过程的上游或内部发挥作用,包括线粒体DNA复制;通过p53类介体内在凋亡信号通路负调控;以及核苷酸磷酸代谢过程。预测位于核质中。预测在细胞质中活性。在几个结构中表达,包括消化系统;生殖系统;神经系统;呼吸系统;和感觉器官。这个基因的人类同源物与常染色体显性进行性外眼肌麻痹有关,伴有线粒体DNA缺失5;线粒体DNA耗竭综合征8a;和线粒体DNA耗竭综合征8b。与人类的RRM2B(核苷酸还原酶调节TP53诱导的M2B亚基)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:382985
ENSEMBL:ENSMUSG00000022292
UNIPROT:Q6PEE3
Basic Information
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MW (kDa)
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Reference
382985
10
9
37367 bp
40.80
6
5
Rrm2b Genetics information (-)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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