Predicted to enable ATP binding activity; protein kinase activity; and small GTPase binding activity. Acts upstream of or within protein localization to nucleus. Predicted to be located in several cellular components, including ciliary tip; dendritic growth cone; and microtubule organizing center. Predicted to be active in dendrite cytoplasm; glutamatergic synapse; and nucleus. Predicted to colocalize with ruffle membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study developmental and epileptic encephalopathy 2. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5). [provided by Alliance of Genome Resources, Apr 2022]