人类
KCNA3 - Potassium Voltage-gated Channel Subfamily A Member 3
Alias:
MK3
HGK5
HLK3
PCN3
HPCN3
KV1.3
HUKIII
钾通道是功能和结构上最复杂的电压门控离子通道。它们的多种功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。在果蝇中已经鉴定出四个与钾通道相关的序列基因——shaker、shaw、shab和shal，每种基因都有人类同源基因。本基因编码钾通道、电压门控、shaker相关亚家族的成员。该成员包含六个膜跨越域，第四段有一个shaker型重复。它属于延迟整流器类，其成员允许神经细胞在动作电位后有效地复极化。它在T细胞增殖和激活中起着关键作用。本基因似乎没有内含子，并且与KCNA2和KCNA10基因在1号染色体上聚集在一起。[由RefSeq提供，2008年7月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
KCNA3 Genetics information (-)
GRCh38
Chr : -
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
