Rac2 - Rac family small GTPase 2

Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin cytoskeleton organization and bone resorption. Predicted to be located in several cellular components, including cytosol; lamellipodium; and nuclear envelope. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Predicted to colocalize with actin filament. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]