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中文人类
IRF4 - Interferon Regulatory Factor 4
Alias:
MUM1
LSIRF
SHEP8
NF-EM5
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这个基因编码的蛋白质属于IRF（干扰素调节因子）家族转录因子，其特征是具有独特的色氨酸五重复DNA结合域。IRF家族在调节干扰素以响应病毒感染以及调节干扰素诱导的基因中起着重要作用。这个家族成员是淋巴细胞特异性的，并负调控Toll-like受体（TLR）信号传导，这是激活先天和适应性免疫系统的关键。涉及这个基因和IgH位点的染色体易位，t(6;14)(p25;q32)，可能是多发性骨髓瘤的一个原因。已经发现这个基因的替代剪接转录变异体。[RefSeq，2010年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
IRF4 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
