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中文人类
ITGA6 - Integrin Subunit Alpha 6
Alias:
JEB6
CD49f
VLA-6
ITGA6A
ITGA6B
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该基因编码整合素α链家族蛋白质的一员。整合素是异源二聚体整膜蛋白质，由α链和β链组成，在细胞表面粘附和信号传导中发挥作用。编码的前原蛋白被蛋白水解加工，产生组成α6亚基的重链和轻链。这个亚基可以与β1或β4亚基结合，形成与细胞外基质蛋白（包括层粘连蛋白家族成员）相互作用的整合素。α6β4整合素可能促进肿瘤发生，而α6β1整合素可能负调节erbB2/HER2信号传导。可变剪接产生多种转录变异体。[RefSeq，2015年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ITGA6 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
