Log In|Sign Up
中文人类
INSR - Insulin Receptor
Alias:
HHF5
CD220
Favorite
这个基因编码一种受体酪氨酸激酶家族的蛋白质成员。编码的前原蛋白在蛋白水解过程中被加工成α和β亚基，形成异四聚体受体。胰岛素或其他配体结合到这个受体上，激活胰岛素信号通路，该通路调节葡萄糖的摄取和释放，以及碳水化合物的合成和储存，脂质和蛋白质。这个基因中的突变导致了遗传性严重胰岛素抵抗综合征，包括A型胰岛素抵抗综合征、Donohue综合征和Rabson-Mendenhall综合征。可变剪接产生了多种转录变异体。[RefSeq，2015年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
INSR Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
