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中文人类
INSIG1 - Insulin Induced Gene 1
Alias:
CL6
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这个基因编码一个内质网膜蛋白，可调节胆固醇代谢、脂生成和血糖平衡。编码的蛋白质有六个跨膜螺旋，包含一个效应蛋白结合位点。它结合胆固醇感受元件结合蛋白（SREBP）切割激活蛋白（SCAP）和3-羟基-3-甲基戊酸辅酶A还原酶（HMG-CoA还原酶）的固醇感受结构域，对于这两个蛋白质的固醇介导的转运是必需的。它促进SCAP的内质网保留和HMG-CoA还原酶的泛素介导降解。可变剪接产生多个转录变异体。[RefSeq，2016年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
INSIG1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
