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中文人类
INS - Insulin
Alias:
IDDM
ILPR
IRDN
IDDM1
IDDM2
PNDM4
MODY10
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这个基因编码胰岛素，一种在调节碳水化合物和脂质代谢中起重要作用的肽类激素。在去除前导信号肽后，胰岛素原在翻译后裂解成三个肽：B链和A链肽，它们通过两个二硫键共价连接形成胰岛素，以及C肽。胰岛素与胰岛素受体（INSR）结合刺激葡萄糖摄取。已经鉴定出多种具有表型效应的突变等位基因，包括胰岛素依赖型糖尿病、永久性新生儿糖尿病、成年起病的青少年糖尿病1型以及高胰岛素血症。存在一个穿透基因INS-IGF2，它在5'区域与这个基因重叠，在3'区域与IGF2基因重叠。[由RefSeq，2020年5月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
INS Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
