Topors - TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase

Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of ubiquitin-protein transferase activity; and protein modification by small protein conjugation. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription, DNA-templated; and regulation of cell population proliferation. Predicted to be located in centriole; nucleoplasm; and spindle pole. Predicted to be part of gamma-tubulin complex and ubiquitin ligase complex. Predicted to be active in ciliary basal body; nuclear speck; and photoreceptor connecting cilium. Predicted to colocalize with PML body. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]