Enables deoxyribonuclease activity. Involved in several processes, including neuron death in response to oxidative stress; positive regulation of apoptotic DNA fragmentation; and positive regulation of hydrogen peroxide-mediated programmed cell death. Located in several cellular components, including cytosol; mitochondrion; and perikaryon. Biomarker of brain ischemia; congestive heart failure; muscular atrophy; and visual epilepsy. Orthologous to human ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Apr 2022]