Macroh2a2 - macroH2A.2 histone

Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and chromatin DNA binding activity. Predicted to be involved in several processes, including establishment of protein localization to chromatin; negative regulation of macromolecule metabolic process; and positive regulation of keratinocyte differentiation. Predicted to act upstream of or within dosage compensation and negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Orthologous to human MACROH2A2 (macroH2A.2 histone). [provided by Alliance of Genome Resources, Apr 2022]