Dhtkd1 - dehydrogenase E1 and transketolase domain containing 1

Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity and thiamine pyrophosphate binding activity. Predicted to be involved in generation of precursor metabolites and energy. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]