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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
ILF3 - Interleukin Enhancer Binding Factor 3
Alias:
CBTF
DRBF
MMP4
MPP4
NF90
NFAR
NF110
NF90a
NF90b
NF90c
NFAR2
TCP80
DRBP76
NF110b
NFAR-1
NFAR-2
NFAR90
TCP110
MPP4110
NF90ctv
NFAR110
MPHOSPH4
NF-AT-90
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一个双链RNA(dsRNA)结合蛋白,该蛋白与其它蛋白质、dsRNAs、小非编码RNA和mRNA复合,以调节基因表达并稳定mRNA。这个蛋白(NF90,ILF3)与一个45kDa的转录因子(NF45,ILF2)形成异二聚体,这是T细胞表达白细胞介素2所必需的。这个复合物已被证明会影响核mRNA向细胞质的重新分布。NF45或NF90蛋白的敲除会延缓细胞生长,可能是通过抑制mRNA的稳定化。然而,这个基因的一个主要位于核内的异构体(NF110)在减少其水平时对细胞生长只有轻微影响。选择性剪接导致编码不同异构体的多种转录变异体。[RefSeq,2014年12月提供]
Related ID:
NCBI:3609
ENSEMBL:ENSG00000129351
HGNC:6038
UNIPROT:Q12906
OMIM:603182
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3609
28
20
38055 bp
95.34
24
--
8
41
ILF3 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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* This data comes from NCBI.
Gene Expression
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