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中文人类
IL18 - Interleukin 18
Alias:
IGIF
IL-18
IL-1g
IL1F4
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这个基因编码的蛋白质是一种IL-1家族的促炎细胞因子，它在各种细胞的胞质中组成性地作为前体存在，包括巨噬细胞和角质细胞。无活性的IL-18前体被caspase-1加工成其活性形式，能够刺激干扰素γ的产生，并调节T辅助细胞（Th）1和Th2反应。这种细胞因子与不同器官的损伤和由细胞因子风暴引起的潜在致命状况有关。在人类中，IL-18基因位于染色体11上。已经发现这个基因有不同的剪接转录变异体，它们编码不同的异构体。[RefSeq，2020年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
IL18 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
