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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL15 - Interleukin 15
Alias:
IL-15
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种调节T细胞和自然杀伤细胞激活和增殖的细胞因子。这种细胞因子和白介素2具有许多共同的生物活性。它们被发现结合共同的造血受体亚单位,可能竞争相同的受体,从而负向调节彼此的活动。CD8+记忆细胞的数量显示是由这种细胞因子和IL2之间的平衡控制的。这种细胞因子诱导JAK激酶的激活,以及转录激活物STAT3、STAT5和STAT6的磷酸化和激活。研究小鼠对应物表明,这种细胞因子可能通过STAT6的转录激活活性增加凋亡抑制剂BCL2L1/BCL-x(L)的表达,从而防止凋亡。已经报道了这个基因的替代剪接转录变异体。[RefSeq,2011年2月提供]
Related ID:
NCBI:3600
ENSEMBL:ENSG00000164136
HGNC:5977
UNIPROT:P40933
OMIM:600554
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3600
2
8
97405 bp
18.09
7
--
13
13
IL15 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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Score
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No data available
Transcripts & Proteins
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Transcript
Length(nt)
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Alphabetical
Cell-specific RNA expression
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Interactions
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Related Mouse Models
Type
Name
MGI
Strain of Origin
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Mutations
No data available
Related Drugs
Name
CAS Number
Status
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Link
No data available
References Literature
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IF
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