人类

IL15 - Interleukin 15

Alias:
IL-15
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种调节T细胞和自然杀伤细胞激活和增殖的细胞因子。这种细胞因子和白介素2具有许多共同的生物活性。它们被发现结合共同的造血受体亚单位,可能竞争相同的受体,从而负向调节彼此的活动。CD8+记忆细胞的数量显示是由这种细胞因子和IL2之间的平衡控制的。这种细胞因子诱导JAK激酶的激活,以及转录激活物STAT3、STAT5和STAT6的磷酸化和激活。研究小鼠对应物表明,这种细胞因子可能通过STAT6的转录激活活性增加凋亡抑制剂BCL2L1/BCL-x(L)的表达,从而防止凋亡。已经报道了这个基因的替代剪接转录变异体。[RefSeq,2011年2月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
8
97405 bp
18.09
7
--
13
13

IL15 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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