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中文人类
IL12RB2 - Interleukin 12 Receptor Subunit Beta 2
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这个基因编码的蛋白质是一种I型跨膜蛋白，被鉴定为白细胞介素12受体复合物的亚单位。这个基因与IL12RB1蛋白的共同表达可以形成高亲和力的IL12结合位点，并重建IL12依赖的信号传导。这个基因在Th1细胞中由干扰素γ上调表达，并在Th1细胞分化中发挥作用。这个基因的上调表达与许多感染性疾病（如克罗恩病和麻疯病）有关，被认为有助于炎症反应和宿主防御。这个基因的几个转录变异体编码不同的异构体和非编码蛋白质的转录本已经被发现。[由RefSeq，2012年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
IL12RB2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
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Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
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Score
Related Mouse Models
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Name
MGI
Strain of Origin
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Mutations
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CAS Number
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Phase
Link
References Literature
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Year
IF
