人类

IL12B - Interleukin 12B

Alias:
CLMF
NKSF
CLMF2
IMD28
IMD29
NKSF2
IL-12B
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码白细胞介素12的亚单位,白细胞介素12是一种对T细胞和自然杀伤细胞有作用的细胞因子,具有广泛的生物活性。白细胞介素12是一个由这个基因编码的40kD的细胞因子受体样亚单位和一个由IL12A编码的35kD亚单位通过二硫键连接而成的异源二聚体。这个细胞因子由激活的巨噬细胞表达,作为Th1细胞发育的必要诱导剂。这个细胞因子对于维持足够的记忆/效应Th1细胞以介导对细胞内病原体的长期保护作用非常重要。在多发性硬化症(MS)患者的中枢神经系统中,这个基因的过度表达被观察到,这表明这个细胞因子在疾病的发病机制中发挥作用。这个基因的启动子多态性已被报道与儿童特应性和非特应性哮喘的严重程度相关。[RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
8
15708 bp
37.17
189
2
7
16

IL12B Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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