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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL12A - Interleukin 12A
Alias:
P35
CLMF
NFSK
NKSF1
IL-12A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一种细胞因子亚单位,该细胞因子作用于T细胞和自然杀伤细胞,具有广泛的生物活性。细胞因子是一个由二硫键连接的异源二聚体,由这个基因编码的35kD亚单位和一个属于细胞因子受体家族的40kD亚单位组成。这个细胞因子对于T细胞非依赖性的干扰素(IFN)-γ的诱导是必需的,对于Th1和Th2细胞的分化都很重要。淋巴细胞对这个细胞因子的反应是通过转录激活蛋白STAT4介导的。一氧化氮合酶2A(NOS2A/NOS2)被发现在先天免疫中这个细胞因子的信号传导过程中是必需的。[由RefSeq,2008年7月提供]
Related ID:
NCBI:3592
ENSEMBL:ENSG00000168811
HGNC:5969
UNIPROT:P29459
OMIM:161560
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3592
4
7
7185 bp
24.87
10
2
7
16
IL12A Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
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Interactions
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Regulation
Detail
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Residues
Reference
Score
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Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available
Related Drugs
Name
CAS Number
Status
Phase
Link
No data available
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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