人类

IL12A - Interleukin 12A

Alias:
P35
CLMF
NFSK
NKSF1
IL-12A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码一种细胞因子亚单位,该细胞因子作用于T细胞和自然杀伤细胞,具有广泛的生物活性。细胞因子是一个由二硫键连接的异源二聚体,由这个基因编码的35kD亚单位和一个属于细胞因子受体家族的40kD亚单位组成。这个细胞因子对于T细胞非依赖性的干扰素(IFN)-γ的诱导是必需的,对于Th1和Th2细胞的分化都很重要。淋巴细胞对这个细胞因子的反应是通过转录激活蛋白STAT4介导的。一氧化氮合酶2A(NOS2A/NOS2)被发现在先天免疫中这个细胞因子的信号传导过程中是必需的。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
4
7
7185 bp
24.87
10
2
7
16

IL12A Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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